MtrR Modulates rpoH Expression and Levels of Antimicrobial Resistance in Neisseria gonorrhoeae

MtrR modulates rpoH expression and levels of antimicrobial resistance in Neisseria gonorrhoeae.

The MtrR transcriptional-regulatory protein is known to repress transcription of the mtrCDE operon, which encodes a multidrug efflux pump possessed by Neisseria gonorrhoeae that is important in the ability of gonococci to resist certain hydrophobic antibiotics, detergents, dyes, and host-derived antimicrobials. In order to determine whether MtrR can exert regulatory action on other gonococcal g...

Antimicrobial resistance in Neisseria gonorrhoeae

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Antimicrobial Resistance and Neisseria gonorrhoeae

Clinical Features N. gonorrhoeae causes infection of mucosal membranes including the cervix, rectum, and throat. If untreated, gonorrhea remains a major cause of pelvic inflammatory disease (PID), tubal infertility, ectopic pregnancy, and chronic pelvic pain. Epidemiologic studies provide strong evidence that gonococcal infections facilitate HIV transmission. Incidence Gonorrhea, caused by Neis...

Phase variable expression of lptA modulates resistance of Neisseria gonorrhoeae to cationic antimicrobial 1 peptides

Phase-variable expression of lptA modulates the resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides.

Phosphoethanolamine (PEA) decoration of lipid A produced by Neisseria gonorrhoeae has been linked to bacterial resistance to cationic antimicrobial peptides/proteins (CAMPs) and in vivo fitness during experimental infection. We now report that the lptA gene, which encodes the PEA transferase responsible for this decoration, is in an operon and that high-frequency mutation in a polynucleotide re...